The recommended dose is one 200 mg DIFICID tablet orally twice daily for 10 days with or without food1
No dose adjustment needed1
No significant drug interactions1
Important Safety Information
DIFICID is contraindicated in patients with hypersensitivity to fidaxomicin
DIFICID should not be used for systemic infections
Acute hypersensitivity reactions (angioedema, dyspnea, pruritus, and rash) have been reported. In the event of a severe reaction, discontinue DIFICID.
Only use DIFICID for infection proven or strongly suspected to be caused by C. difficile.
Prescribing DIFICID in the absence of a proven or strongly suspected C. difficile infection is unlikely to provide benefit to the patient and increases the risk of the development of drug- resistant bacteria.
The most common adverse reactions reported in clinical trials are nausea (11%), vomiting (7%), abdominal pain (6%), gastrointestinal hemorrhage (4%), anemia (2%), and neutropenia (2%)
Indications and Usage
DIFICID is a macrolide antibacterial drug indicated in adults ≥18 years of age for treatment of Clostridium difficile-associated diarrhea
To reduce the development of drug-resistant bacteria and maintain the effectiveness of DIFICID and other antibacterial drugs, DIFICID should be used only to treat infections that are proven or strongly suspected to be caused by Clostridium difficile
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